219 research outputs found
A rare and exclusive endoperoxide photoproduct derived from thiacalix[4]arene crown-shaped derivative bearing 9,10-substituted anthracene moiety
A rare and exclusive endoperoxide photoproduct was quantitatively obtained from a thiacalix[4]arene crown-shaped derivative upon irradiation at λ=365 nm; the structure was unambiguously confirmed by 1H/13C NMR spectroscopy and X-ray crystallography. The prerequisites for the formation of the endoperoxide photoproduct have also been discussed. Furthermore, the photochemical reaction rate could be greatly enhanced in the presence of the thiacalix[4]arene platform because it served as a host to capture oxygen
Beyond Einstein-Cartan gravity: Quadratic torsion and curvature invariants with even and odd parity including all boundary terms
Recently, gravitational gauge theories with torsion have been discussed by an
increasing number of authors from a classical as well as from a quantum field
theoretical point of view. The Einstein-Cartan(-Sciama-Kibble) Lagrangian has
been enriched by the parity odd pseudoscalar curvature (Hojman, Mukku, and
Sayed) and by torsion square and curvature square pieces, likewise of even and
odd parity. (i) We show that the inverse of the so-called Barbero-Immirzi
parameter multiplying the pseudoscalar curvature, because of the topological
Nieh-Yan form, can only be appropriately discussed if torsion square pieces are
included. (ii) The quadratic gauge Lagrangian with both parities, proposed by
Obukhov et al. and Baekler et al., emerges also in the framework of Diakonov et
al.(2011). We establish the exact relations between both approaches by applying
the topological Euler and Pontryagin forms in a Riemann-Cartan space expressed
for the first time in terms of irreducible pieces of the curvature tensor.
(iii) Only in a Riemann-Cartan spacetime, that is, in a spacetime with torsion,
parity violating terms can be brought into the gravitational Lagrangian in a
straightforward and natural way. Accordingly, Riemann-Cartan spacetime is a
natural habitat for chiral fermionic matter fields.Comment: 12 page latex, as version 2 an old file was submitted by mistake,
this is now the real corrected fil
Search for Event Rate Modulation in XENON100 Electronic Recoil Data
We have searched for periodic variations of the electronic recoil event rate
in the (2-6) keV energy range recorded between February 2011 and March 2012
with the XENON100 detector, adding up to 224.6 live days in total. Following a
detailed study to establish the stability of the detector and its background
contributions during this run, we performed an un-binned profile likelihood
analysis to identify any periodicity up to 500 days. We find a global
significance of less than 1 sigma for all periods suggesting no statistically
significant modulation in the data. While the local significance for an annual
modulation is 2.8 sigma, the analysis of a multiple-scatter control sample and
the phase of the modulation disfavor a dark matter interpretation. The
DAMA/LIBRA annual modulation interpreted as a dark matter signature with
axial-vector coupling of WIMPs to electrons is excluded at 4.8 sigma.Comment: 6 pages, 4 figure
Search for Two-Neutrino Double Electron Capture of Xe with XENON100
Two-neutrino double electron capture is a rare nuclear decay where two
electrons are simultaneously captured from the atomic shell. For Xe
this process has not yet been observed and its detection would provide a new
reference for nuclear matrix element calculations. We have conducted a search
for two-neutrino double electron capture from the K-shell of Xe using
7636 kgd of data from the XENON100 dark matter detector. Using a
Bayesian analysis we observed no significant excess above background, leading
to a lower 90 % credibility limit on the half-life
yr. We also evaluated the sensitivity of the XENON1T experiment, which is
currently being commissioned, and find a sensitivity of
yr after an exposure of 2 tyr.Comment: 6 pages, 4 figure
Removing krypton from xenon by cryogenic distillation to the ppq level
The XENON1T experiment aims for the direct detection of dark matter in a
cryostat filled with 3.3 tons of liquid xenon. In order to achieve the desired
sensitivity, the background induced by radioactive decays inside the detector
has to be sufficiently low. One major contributor is the -emitter
Kr which is an intrinsic contamination of the xenon. For the XENON1T
experiment a concentration of natural krypton in xenon Kr/Xe < 200
ppq (parts per quadrillion, 1 ppq = 10 mol/mol) is required. In this
work, the design of a novel cryogenic distillation column using the common
McCabe-Thiele approach is described. The system demonstrated a krypton
reduction factor of 6.410 with thermodynamic stability at process
speeds above 3 kg/h. The resulting concentration of Kr/Xe < 26 ppq
is the lowest ever achieved, almost one order of magnitude below the
requirements for XENON1T and even sufficient for future dark matter experiments
using liquid xenon, such as XENONnT and DARWIN
Neuroticism Modifies Psychophysiological Responses to Fearful Films
Background: Neuroticism is a personality component frequently found in anxious and depressive psychiatric disorders. The influence of neuroticism on negative emotions could be due to its action on stimuli related to fear and sadness, but this remains debated. Our goal was thus to better understand the impact of neuroticism through verbal and physiological assessment in response to stimuli inducing fear and sadness as compared to another negative emotion (disgust).¦Methods: Fifteen low neurotic and 18 high neurotic subjects were assessed on an emotional attending task by using film excerpts inducing fear, disgust, and sadness. We recorded skin conductance response (SCR) and corrugator muscle activity (frowning) as indices of emotional expression.¦Results: SCR was larger in high neurotic subjects than in low neurotics for fear relative to sadness and disgust. Moreover, corrugator activity and SCR were larger in high than in low neurotic subjects when fear was induced.¦Conclusion: After decades of evidence that individuals higher in neuroticism experience more intense emotional reactions to even minor stressors, our results indicate that they show greater SCR and expressive reactivity specifically to stimuli evoking fear rather than to those inducing sadness or disgust. Fear processing seems mainly under the influence of neuroticism. This modulation of autonomic activity by neurotics in response to threat/fear may explain their increased vulnerability to anxious psychopathologies such as PTSD (post traumatic stress disorder)
Masked mRNA is stored with aggregated nuclear speckles and its asymmetric redistribution requires a homolog of mago nashi
<p>Abstract</p> <p>Background</p> <p>Many rapidly developing systems rely on the regulated translation of stored transcripts for the formation of new proteins essential for morphogenesis. The microspores of the water fern <it>Marsilea vestita </it>dehydrate as they mature. During this process both mRNA and proteins required for subsequent development are stored within the microspores as they become fully desiccated and enter into senescence. At this point microspores become transcriptionally silent and remain so upon rehydration and for the remainder of spermatogenesis. Transcriptional silencing coupled with the translation of preformed RNA makes the microspore of <it>M. vestita </it>a useful system in which to study post-transcriptional regulation of RNA.</p> <p>Results</p> <p>We have characterized the distribution of mRNA as well as several conserved markers of subnuclear bodies within the nuclei of desiccating spores. During this period, nuclear speckles containing RNA were seen to aggregate forming a single large coalescence. We found that aggregated speckles contain several masked mRNA species known to be essential for spermatogenesis. During spermatogenesis masked mRNA and associated speckle proteins were shown to fragment and asymmetrically localize to spermatogenous but not sterile cells. This asymmetric localization was disrupted by RNAi knockdown of the <it>Marsilea </it>homolog of the Exon Junction Complex core component Mago nashi.</p> <p>Conclusions</p> <p>A subset of masked mRNA is stored in association with nuclear speckles during the dormant phase of microspore development in <it>M. vestita</it>. The asymmetric distribution of specific mRNAs to spermatogenous but not sterile cells mirrors their translational activities and appears to require the EJC or EJC components. This suggests a novel role for nuclear speckles in the post-transcriptional regulation of transcripts.</p
Multivalent glycoconjugates as vaccines and potential drug candidates
Pathogens adhere to the host cells during the first steps of infection through
multivalent interactions which involve protein–glycan recognition. Multivalent
interactions are also involved at different stages of immune response.
Insights into these multivalent interactions generate a way to use suitable
carbohydrate ligands that are attached to a basic scaffold consisting of e.g.,
dendrimer, polymer, nanoparticle, etc., with a suitable linker. Thus a
multivalent architecture can be obtained with controllable spatial and
topology parameters which can interfere with pathogen adhesion. Multivalent
glycoconjugates bearing natural or unnatural carbohydrate antigen epitopes
have also been used as carbohydrate based vaccines to stimulate an innate and
adaptive immune response. Designing and synthesizing an efficient multivalent
architecture with optimal ligand density and a suitable linker is a
challenging task. This review presents a concise report on the endeavors to
potentially use multi- and polyvalent glycoconjugates as vaccines as well as
anti-infectious and anti-inflammatory drug candidates
Search for Two-Neutrino Double Electron Capture of <sup>124</sup>Xe with XENON100
Two-neutrino double electron capture is a rare nuclear decay where two electrons are simultaneously captured from the atomic shell. For Xe this process has not yet been observed and its detection would provide a new reference for nuclear matrix element calculations. We have conducted a search for two-neutrino double electron capture from the K-shell of Xe using 7636 kgd of data from the XENON100 dark matter detector. Using a Bayesian analysis we observed no significant excess above background, leading to a lower 90 % credibility limit on the half-life yr. We also evaluated the sensitivity of the XENON1T experiment, which is currently being commissioned, and find a sensitivity of yr after an exposure of 2 tyr
Online Rn removal by cryogenic distillation in the XENON100 experiment
We describe the purification of xenon from traces of the radioactive noble gas radon using a cryogenic distillation column. The distillation column was integrated into the gas purification loop of the XENON100 detector for online radon removal. This enabled us to significantly reduce the constant ²²²Rn background originating from radon emanation. After inserting an auxiliary ²²²Rn emanation source in the gas loop, we determined a radon reduction factor of R>27 (95% C.L.) for the distillation column by monitoring the ²²²Rn activity concentration inside the XENON100 detector
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